Position/Role
M&I Ph.D Student
Contact
siyunw[at]msl.ubc.ca
Research Interests
Epigenomics, SWI/SNF complex, ATAC-seq, Ovarian Cancer
Project description
ARID1A is mutated in 57% of Ovarian Clear Cell Carcinoma (OCCC), Ovarian Clear Cell Carcinoma represents 5% of all epithelial ovarian cancer. ARID1A encodes for the protein BAF250a, a component of SWI/SNF chromatin remodeling complex, which utilizes the energy of ATP hydrolysis to localize nucleosomes and modulate chromatin structure. The loss of function ARID1A mutation has been observed in a variety of tumor types with different mutation rates; its mechanism of tumor suppression has not yet been elucidated. The objective of this project is to better understand the role of ARID1A mutation in SWI/SNF complex by mapping the nucleosome occupancy using ATAC-seq to better understand the disease mechanism in the model of rare tumors of OCCC.
Publications
Wang, S., I. M. Hafez, J. Wang, M. Ashtari, D. P. Tieleman, P. R. Cullis and J. L. Thewalt (2014). “Optimizing Drug Release: Bilayer to Inverted Hexagonal Phase Transition of Cationic XTC2 and Anionic DSPS Lipid System is Influenced by pH, Temperature, and Salt Concentration.” Biophysical Journal 106(2): 700a-700a.
Leavens, F. M. V., C. D. M. Churchill, S. Y. Wang and S. D. Wetmore (2011). “Evaluating How Discrete Water Molecules Affect Protein DNA pi-pi and pi(+)-pi Stacking and T-Shaped Interactions: The Case of Histidine-Adenine Dimers.” Journal of Physical Chemistry B 115(37): 10990-11003