Epigenomics, Cancer genomics, Bioinformatics, Sequencing data analysis
Bioinformatics PhD candidate
Role of RUNX1 in Notch signaling
T-cell acute lymphoblastic leukemia (T-ALL) is a hematopoietic malignancy driven by oncogenic activation of Notch signaling. T-ALL accounts for 15% of pediatric and 25% of adult acute lymphoblastic leukemia cases. In T-ALL patients Notch1 signalling activity is increased. Runt-related transcription factor 1 (RUNX1) works as pioneer factor in supporting Notch signalling, which is well characterized as an oncogenic pathway in T-cell leukemia. In order to dissect the molecular mechanism(s), we applied genomic and epigenomic technologies, specially next generation sequencing. The goal of the project is to understand the gene expression change due to chromatin restructuring mediated by polycomb repressive complex and histone acetyl transferases in a NOTCH1 and RUNX1 dependent manner as well as to construct the transcriptional regulatory networks in T-cell resulting T-ALL.
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